Publications

Publications by Prof. Valerio Sanguigni

Publications by Prof. Valerio Sanguigni
Different degrees of NADPH oxidase 2 regulation and in vivo platelet activation: lesson from chronic granulomatous disease.
Carnevale R, Loffredo L, Sanguigni V, Plebani A, Rossi P, Pignata C, Martire B, Finocchi A, Pietrogrande MC, Azzari C, Soresina AR, Martino S, Cirillo E, Martino F, Pignatelli P, Violi F.
J Am Heart Assoc. 2014 Jun 27;3.

Reduced atherosclerotic burden in subjects with genetically determined low oxidative stress.
Violi F, Pignatelli P, Pignata C, Plebani A, Rossi P, Sanguigni V, Carnevale R, Soresina A, Finocchi A, Cirillo E, Catasca E, Angelico F, Loffredo L.
Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):406-12.

Does NADPH oxidase deficiency cause artery dilatation in humans?
Loffredo L, Carnevale R, Sanguigni V, Plebani A, Rossi P, Pignata C, De Mattia D, Finocchi A, Martire B, Pietrogrande MC, Martino S, Gambineri E, Giardino G, Soresina AR, Martino F, Pignatelli P, Violi F.
Antioxid Redox Signal. 2013 Apr 20;18(12):1491-6.

Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction.
Pignatelli P, Carnevale R, Di Santo S, Bartimoccia S, Sanguigni V, Lenti L, Finocchi A, Mendolicchio L, Soresina AR, Plebani A, Violi F.
Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):423-34.

Atorvastatin inhibits oxidative stress via adiponectin-mediated NADPH oxidase down-regulation in hypercholesterolemic patients.
Carnevale R, Pignatelli P, Di Santo S, Bartimoccia S, Sanguigni V, Napoleone L, Tanzilli G, Basili S, Violi F.
Atherosclerosis. 2010 Nov;213(1):225-34. doi: 10.1016/j.atherosclerosis.2010.08.056.

Atorvastatin inhibits gp91phox circulating levels in patients with hypercholesterolemia.
Pignatelli P, Carnevale R, Cangemi R, Loffredo L, Sanguigni V, Stefanutti C, Basili S, Violi F.
Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):360-7. doi: 10.1161/ATVBAHA.109.198622. Epub 2009 Dec 3. Erratum in: Arterioscler Thromb Vasc Biol. 2014 Sep;34.

Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study.
Violi F, Sanguigni V, Carnevale R, Plebani A, Rossi P, Finocchi A, Pignata C, De Mattia D, Martire B, Pietrogrande MC, Martino S, Gambineri E, Soresina AR, Pignatelli P, Martino F, Basili S, Loffredo L.
Circulation. 2009 Oct 20;120(16):1616-22. 

Oxidative stress is associated with arterial dysfunction and enhanced intima-media thickness in children with hypercholesterolemia: the potential role of nicotinamide-adenine dinucleotide phosphate oxidase.
Martino F, Loffredo L, Carnevale R, Sanguigni V, Martino E, Catasca E, Zanoni C, Pignatelli P, Violi F.
Pediatrics. 2008 Sep;122(3):e648-55.

Early decrease of oxidative stress by atorvastatin in hypercholesterolaemic patients: effect on circulating vitamin E.
Cangemi R, Loffredo L, Carnevale R, Perri L, Patrizi MP, Sanguigni V, Pignatelli P, Violi F.
Eur Heart J. 2008 Jan;29(1):54-62.

Oxidative stress-mediated platelet CD40 ligand upregulation in patients with hypercholesterolemia: effect of atorvastatin.
Pignatelli P, Sanguigni V, Lenti L, Loffredo L, Carnevale R, Sorge R, Violi F.
J Thromb Haemost. 2007 Jun;5(6):1170-8. 

LDL are oxidatively modified by platelets via GP91(phox) and accumulate in human monocytes.
Carnevale R, Pignatelli P, Lenti L, Buchetti B, Sanguigni V, Di Santo S, Violi F.
FASEB J. 2007 Mar;21(3):927-34.

Nox2 is determinant for ischemia-induced oxidative stress and arterial vasodilatation: a pilot study in patients with hereditary Nox2 deficiency.
Violi F, Sanguigni V, Loffredo L, Carnevale R, Buchetti B, Finocchi A, Tesauro M, Rossi P, Pignatelli P.
Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):e131-2.

Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation: effect on platelet recruitment.
Pignatelli P, Di Santo S, Buchetti B, Sanguigni V, Brunelli A, Violi F.
FASEB J. 2006 Jun;20(8):1082-9.

Early anticoagulant effect of atorvastatin.
Pignatelli P, Sanguigni V, Buchetti B, Lenti L, Violi F.
Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):e145; author reply e145-6. No abstract available.

Vitamin C inhibits platelet expression of CD40 ligand.
Pignatelli P, Sanguigni V, Paola SG, Lo Coco E, Lenti L, Violi F.
Free Radic Biol Med. 2005 Jun 15;38(12):1662-6. 

Short-term treatment with atorvastatin reduces platelet CD40 ligand and thrombin generation in hypercholesterolemic patients.
Sanguigni V, Pignatelli P, Lenti L, Ferro D, Bellia A, Carnevale R, Tesauro M, Sorge R, Lauro R, Violi F.
Circulation. 2005 Feb 1;111(4):412-9.

CD40 ligand enhances monocyte tissue factor expression and thrombin generation via oxidative stress in patients with hypercholesterolemia.
Sanguigni V, Ferro D, Pignatelli P, Del Ben M, Nadia T, Saliola M, Sorge R, Violi F.
J Am Coll Cardiol. 2005 Jan 4;45(1):35-42.

gp91phox-dependent expression of platelet CD40 ligand.
Pignatelli P, Sanguigni V, Lenti L, Ferro D, Finocchi A, Rossi P, Violi F.
Circulation. 2004 Sep 7;110(10):1326-9. 

Enhanced platelet release of superoxide anion in systemic hypertension: role of AT1 receptors.
Germanò G, Sanguigni V, Pignatelli P, Caccese D, Lenti L, Ragazzo M, Lauro R, Violi F.
J Hypertens. 2004 Jun;22(6):1151-6.

Carnitine inhibits arachidonic acid turnover, platelet function, and oxidative stress.
Pignatelli P, Lenti L, Sanguigni V, Frati G, Simeoni I, Gazzaniga PP, Pulcinelli FM, Violi F.
Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H41-8. 

Increased superoxide anion production by platelets in hypercholesterolemic patients.
Sanguigni V, Pignatelli P, Caccese D, Pulcinelli FM, Lenti L, Magnaterra R, Martini F, Lauro R, Violi F.
Thromb Haemost. 2002 May;87(5):796-801.

Metformin decreases platelet superoxide anion production in diabetic patients.
Gargiulo P, Caccese D, Pignatelli P, Brufani C, De Vito F, Marino R, Lauro R, Violi F, Di Mario U, Sanguigni V.
Diabetes Metab Res Rev. 2002 Mar-Apr;18(2):156-9.

Superoxide anion and hydroxyl radical release by collagen-induced platelet aggregation--role of arachidonic acid metabolism.
Caccese D, Praticò D, Ghiselli A, Natoli S, Pignatelli P, Sanguigni V, Iuliano L, Violi F.
Thromb Haemost. 2000 Mar;83(3):485-90.

Effect of amlodipine on exercise-induced platelet activation in patients affected by chronic stable angina.
Sanguigni V, Gallù M, Sciarra L, Del Principe D, Menichelli A, Palumbo G, Cannata D, Strano A.
Clin Cardiol. 1999 Sep;22(9):575-80.

Effects of coffee on serum cholesterol and lipoproteins: the Italian brewing method. Italian Group for the Study of Atherosclerosis and Dismetabolic Diseases, Rome II Center.
Sanguigni V, Gallu M, Ruffini MP, Strano A.
Eur J Epidemiol. 1995 Feb;11(1):75-8.

[Therapy and prevention of infective endocarditis].
Rocchi G, Sordillo P, Sarrecchia C, Sanguigni V.
Cardiologia. 1994 Dec;39(12 Suppl 1):267-74. Review. Italian.

[Effects of physical activity on lipids and coagulation].
Sanguigni V, Gallù M, De Cristofaro R, Ruffini MP, Levi C, Sciarra L, Novo S, Strano A.
Cardiologia. 1994 Jun;39(6):425-31. Italian. 

Cholesterol and fibrinogen as predictive factors of progressive carotid atherosclerosis.
Sanguigni V, Gallù M, Novo S, Strano A.
Int Angiol. 1993 Dec;12(4):335-6.

[Silent myocardial ischemia: prevalence, prognostic significance, diagnosis].
Novo S, Longo B, Liquori M, Abrignani MG, Barbagallo M, Sanguigni V, Barbagallo Sangiorgi G, Strano A.
Cardiologia. 1993 Dec;38(12 Suppl 1):243-51. Italian. 

Incidence of carotid artery atherosclerosis in patients with coronary artery disease.
Sanguigni V, Gallù M, Strano A.
Angiology. 1993 Jan;44(1):34-8.

Evaluation of total anomalous pulmonary venous drainage with cross-sectional colour-flow Doppler echocardiography.
Vitarelli A, Scapato A, Sanguigni V, Caminiti MC.
Eur Heart J. 1986 Mar;7(3):190-5.

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